Clinicopathology and immunohistochemistry of adult type pulmonary blastoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 475-478, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-318881
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic and immunohistochemical features of adult type pulmonary blastoma (PB).</p><p><b>METHOD</b>Four cases of adult type PB were studied with light microscopy and immunohistochemical staining.</p><p><b>RESULTS</b>Three cases of PB were biphasic type and were composed of primitive epithelial component and primitive stromal component; one case of PB was epithelial type and was shown as branching glands with clustered and well-differentiated structure. Immunohistochemical studies showed that AE1/AE3 was positive in the epithelial component in four cases, Vimentin was positive in the stromal component in three cases, thyroid transricption factor-1 was positive in two cases, CD117 was positive in one case, Ki-67 was 2% positive in one case, while P53 was negative in all cases.</p><p><b>CONCLUSIONS</b>The adult type PB is a rarely seen biphasic tumor. It contains a primitive epithelial component and a primitive mesenchymal stroma, which looks like well-differentiated fetal adenocarcinoma. As highly invasive intrathoracic neoplasm, it is mainly found in adult with an unfavorable outcome.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Vimentin
/
Immunohistochemistry
/
Retrospective Studies
/
Follow-Up Studies
/
Pulmonary Blastoma
/
Ki-67 Antigen
/
Lung Neoplasms
/
Metabolism
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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