Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat / 生理学报
Acta Physiologica Sinica
;
(6): 183-186, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-318920
ABSTRACT
To observe the influence of tumor necrosis factor-alpha (TNF-alpha) on differentiation of rat mesencephalic neural stem cells (NSCs), the numbers of neurons, astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using immunocytochemistry technique. The results show that (1) TNF-alpha enhanced the proportions of neurons and oligodendrocytes in progeny of NSCs; and (2) TNF-alpha induced the proliferation of oligodendrocytes derived from NSCs, but the proliferation of astrocytes was not influenced by TNF-alpha. We conclude that the TNF-alpha could influence the application of NSCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Mesencephalon
/
Cell Differentiation
/
Oligodendroglia
/
Astrocytes
/
Tumor Necrosis Factor-alpha
/
Rats, Sprague-Dawley
/
Cell Biology
/
Cell Proliferation
/
Neural Stem Cells
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2003
Type:
Article
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