Effects of Mycobacterium tuberculosis infection on the transcriptional expression of human macrophage gene encoding ion channels and related regulatory elements / 生理学报
Acta Physiologica Sinica
;
(6): 14-18, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-318950
ABSTRACT
Expression microarray was employed in this study to investigate whether the ion channels and their regulatory elements encoding genes participate in the immune response to Mycobacterium tuberculosis infection. The results of a virulent strain were compared with those of the clinically isolated strains. The data demonstrate that K(+), Na(+), Ca(2+) and Cl(-) channels and their regulatory elements, such as the G protein, receptor and second messenger, protein kinase and protein phosphatase were involved in the immune reaction. The clinical strain affected more types of ion channels and respective regulatory elements. The data provides clues for further scrutiny into the role of ion channels and related elements in the interaction between Mycobacterium tuberculosis and host macrophage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tuberculosis
/
Virulence
/
Gene Expression Regulation
/
Allergy and Immunology
/
Regulatory Elements, Transcriptional
/
Genetics
/
Ion Channels
/
Macrophages
/
Microbiology
/
Mycobacterium tuberculosis
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS