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The effect of intraperitoneal heparin on distribution of ACC-M in lung and liver / 华西口腔医学杂志
West China Journal of Stomatology ; (6): 246-247, 2004.
Article in Chinese | WPRIM | ID: wpr-319007
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of intraperitoneal heparin on the adhesion of highly lung metastasic adenoid cystic carcinoma cell line (ACC-M) in lung.</p><p><b>METHODS</b>3HTdR labeled ACC-M cells were injected by intravenous infusion after intraperitoneal injection with 200 units heparin. 4 mice of each group were killed at 2 h, 6 h and 18 h after infusion. The relative radioactivity (CPM) in lung and liver was detected.</p><p><b>RESULTS</b>3H-activity per gram in lung of heparin group was lower than control at the same time. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups in liver (P > 0.05).</p><p><b>CONCLUSION</b>The results of this study suggest that the highly lung metastasis characteristic of ACC-M may be partially inhabited by the use of intraperitoneal heparin.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Salivary Gland Neoplasms / Heparin / Random Allocation / Cell Adhesion / Carcinoma, Adenoid Cystic / Cell Line, Tumor / Injections, Intraperitoneal / Liver Limits: Animals Language: Chinese Journal: West China Journal of Stomatology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Salivary Gland Neoplasms / Heparin / Random Allocation / Cell Adhesion / Carcinoma, Adenoid Cystic / Cell Line, Tumor / Injections, Intraperitoneal / Liver Limits: Animals Language: Chinese Journal: West China Journal of Stomatology Year: 2004 Type: Article