Preparation of lymphatic targeting dosage form: pingyangmycin absorbed on activated carbon nanoparticles / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 183-185, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-319026
ABSTRACT
<p><b>OBJECTIVE</b>To prepare anticancer nanoparticles for targeting therapy for oral cancer lymph node metastasis.</p><p><b>METHODS</b>The activated carbon nanoparticles (CH-NP) were prepared for drug carrier. Pingyangmycin (PYM), a high sensitive anticancer drug for oral squamous cell carcinoma, were selected as model drug. The activated carbon nanoparticles and PYM were mixed with saline and shaken 20 minutes so that PYM was absorbed on activated carbon enough, resulting in a new formulation of PYM (PYM-CH-NP). The absorbency of PYM on activated carbon nanoparticles was evaluated.</p><p><b>RESULTS</b>The diameter distribution for CH-NP ranged form 136 nm, to 540 nm, the average diameter was 176 nm. The proportion of CH-NP to PYM was increased and more absorbency of PYM on activated carbon nanoparticles was achieved.</p><p><b>CONCLUSION</b>The activated carbon nanoparticles has high absorbency of PYM. The new formulation PYM-CH-NP can be used as targeting therapy of cervical lymph node metastasis by peri-cancer submucosal injection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bleomycin
/
Mouth Neoplasms
/
Carbon
/
Pharmacokinetics
/
Carcinoma, Squamous Cell
/
Chemistry
/
Drug Therapy
/
Nanoparticles
/
Injections, Intralymphatic
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS