The association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 158-161, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-319030
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between Fc gamma receptor IIA gene polymorphism and susceptibility to chronic periodontitis in Chinese Han nationality.</p><p><b>METHODS</b>DNA samples were collected with buccal swabs from 63 patients with severe chronic periodontitis(CP), 103 patients with mild to moderate CP and 80 healthy individuals as control. Polymorphism in Fc gamma receptor IIA gene cluster was analyzed with PCR-SSP. The genotype distribution and allele frequency among different groups were compared.</p><p><b>RESULTS</b>It was found that the frequency of Fc gamma RIIA-R/R131 genotype was significantly higher in patients with severe CP (19.05%) compared to that of the healthy controls (P < 0.0125).</p><p><b>CONCLUSION</b>The Fc gamma RIIA-R/R131 genotype may be one of the contributors for the increased susceptibility to severe CP in Chinese Han nationality.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontitis
/
Polymorphism, Genetic
/
Antigens, CD
/
China
/
Polymerase Chain Reaction
/
Chronic Disease
/
Receptors, IgG
/
Genetic Predisposition to Disease
/
Ethnology
/
Gene Frequency
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2004
Type:
Article
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