Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 23-25, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-319069
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of chemotherapy efficacy in tongue squamous cell carcinoma(SCC) with expression level of P-glycoprotein(Pgp), multidrug resistance-associated protein (MRP), lung resistance-related protein (LRP), glutathiones-tranferase (GST-pi), DNA topo-isomerase II alpha (Topo II alpha).</p><p><b>METHODS</b>The expression patterns of Pgp, MRP, LRP, GST-pi and Topo II alpha in 40 patients (pre and post-chemotherapy, respectively) with tongue SCC were examined by immunohistochemically labelled streptavidin bioein method (LsAB).</p><p><b>RESULTS</b>The expression ratios of Pgp, MRP, LRP, GST-pi and Topo II alpha in pre-chemotherapy cases were 47.5%, 50%, 35%, 45%, 82.5%, respectively. No relations between expression of Pgp, MRP, LRP, GST-pi, Topo II alpha and clinic indexes were established (P > 0.05). Expression ratios of Pgp, MRP in post-chemotherapy cases were higher than that in pre-chemotherapy cases (P < 0.05). Expression of Pgp and MRP showed relevance with drug resistance (P < 0.05). The co-expression was common, the ratios of co-expression of Pgp, MRP, GST-pi and MRP, GST-pi in chemotherapy non-responders were 40% and 50%, respectively, but 0 in responders.</p><p><b>CONCLUSION</b>The intrinsic multidrug resistance of tongue SCC is relevant to the effects of Pgp, MRP, GST-pi.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Random Allocation
/
DNA Topoisomerases, Type II
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Vault Ribonucleoprotein Particles
/
Multidrug Resistance-Associated Proteins
/
DNA-Binding Proteins
/
Glutathione S-Transferase pi
/
Genetics
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2004
Type:
Article
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