Effects of aminoguanidine on the expression of NOS in facial nerve and surrounding tissues of traumatic facial paralysis rats / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 7-9, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-319074
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.</p><p><b>METHODS</b>A small dose of aminoguanidine were intraperitoneally injected into rats before and after facial paralysis. The facial nerve and surrounding tissues were cut at different time point. Immunohistochemical ABC method was used to study the changes of NOS expression in facial nerve and surrounding tissues.</p><p><b>RESULTS</b>The inducible NOS immunoreactivity was obvious inhibited in the facial nerve and surrounding tissues in aminoguanidine group.</p><p><b>CONCLUSION</b>Aminoguanidine chronic treatment can obvious inhibit the inducible NOS expression in the facial nerve and surrounding tissues. Aminoguanidine can improve the regeneration of facial nerve and the recovery of traumatic tissues.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Random Allocation
/
Rats, Sprague-Dawley
/
Nitric Oxide Synthase
/
Facial Nerve Injuries
/
Nitric Oxide Synthase Type II
/
Facial Nerve
/
Facial Paralysis
/
Guanidines
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2004
Type:
Article
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