Study on tumor necrosis factor-alpha and interleukin 2 in rat skin allograft / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 471-480, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-319077
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate the histocompatibility of tissue engineered rat skin through studying the effect of TNF-alpha and IL-2 in immunological rejection after rat skin allograft.</p><p><b>METHODS</b>Tissue engineered skin that the basic materials were taken from neonatal SD rats was cultured in lab, grafted to adult Wistar rats. The expressions of TNF-alpha and IL-2 in grafted tissue were detected with immunohistochemical staining and Western blot.</p><p><b>RESULTS</b>The expressions of TNF-alpha and IL-2 were remarkable in skin allograft group, but low in tissue engineered skin group.</p><p><b>CONCLUSION</b>The expressions of TNF-alpha and IL-2 and the immunological rejection were closely related after skin allograft, but the tissue engineered skin has favorable histocompatibility and doesn't arose obvious immunological rejections.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Skin
/
Cells, Cultured
/
Interleukin-2
/
Skin Transplantation
/
Tumor Necrosis Factor-alpha
/
Rats, Wistar
/
Rats, Sprague-Dawley
/
Cell Biology
/
Tissue Engineering
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2003
Type:
Article
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