Expression of human telomerase reverse transcriptase and bcl-2 in ameloblastoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 441-443, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-319086
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of telomerase reverse transcriptase (hTERT) and bcl-2 in ameloblastoma (AB), METHODS:
hTERT mRNA in 54 cases of AB (primary AB 31 cases, recurrent AB 17 cases, malignant AB 4 cases) and 7 cases of oral normal mucosa was detected by in situ hybridization, and bcl-2 by S-P method.</p><p><b>RESULTS</b>The expression of hTERT mRNA was negative or weak in normal oral mucosa (14.3%), moderate or strong in AB (94.4%). There was a significant difference in these two groups (P < 0.001). The difference between the expressions of hTERT in primary, recurrent and malignant AB was significant (P < 0.05). The positive ratio of bcl-2 in AB and normal oral mucosa was respectively 88.0%, 44.4%. There was a significant statistical difference in these two groups (P < 0.001). hTERT mRNA was stronger in recurred or malignantly transformed AB (P < 0.05).</p><p><b>CONCLUSION</b>The expression of hTERT and bcl-2 is stronger in recurred or malignantly transformed AB, and it could be used as an indicator of AB prognosis. Telomerase activity and bcl-2 expression play an important role in genesis and development of AB.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Ameloblastoma
/
Jaw Neoplasms
/
Biomarkers, Tumor
/
Telomerase
/
Proto-Oncogene Proteins c-bcl-2
/
DNA-Binding Proteins
/
Genetics
/
Metabolism
/
Neoplasm Recurrence, Local
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2003
Type:
Article
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