Sperm DNA damage and assisted reproductive technology / 中华男科学杂志
National Journal of Andrology
;
(12): 259-263, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-319231
ABSTRACT
With the introduction of assisted reproductive technology (ART), sperm assessment has developed progressively, from conventional semen routine tests to novel cellular and molecular measures. Sperm DNA damage is a new marker of male fertility, whose genetic mechanism involves abnormal package and segregation of chromatin, oxidative stress, abnormal cell apoptosis, etc. Sperm chromatin structure assay (SCSA) is one of the common techniques to measure sperm DNA damage. Sperm DNA damage might be associated with the pregnancy outcome of ART, recurrent spontaneous abortion and potential genetic risk of ICSI offspring. Some treatment strategies might reduce the percentage of sperm DNA damage and increase the success rate of ART, including oral administration of antioxygen drugs, ICSI with testis sperm, sperm freezing and preservation, removing of etiological factors, traditional Chinese medicine, and so on. This review focuses on the mechanism and detection of sperm DNA damage, its association with reproductive outcomes, and relevant treatment strategies in assisted reproductive technology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatozoa
/
Therapeutics
/
DNA Damage
/
Sperm Injections, Intracytoplasmic
/
Infertility, Male
/
Metabolism
/
Methods
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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