Expression of OCTN2 mRNA in the human epididymis and its significance / 中华男科学杂志
National Journal of Andrology
;
(12): 242-244, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-319236
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of L-Carnitine transport and the expression of OCTN2 mRNA in the human epididymis so as to provide a theoretical basis for male contraception.</p><p><b>METHODS</b>We collected specimens from human epididymides and determined the expressions of OCTN2 mRNA in the caput, corpus and cauda of the epididymis by RT-PCR.</p><p><b>RESULTS</b>OCTN2 mRNA was expressed in the caput, corpus and cauda of the epididymis.</p><p><b>CONCLUSION</b>The human epididymis may rely on OCTN2 for transporting L-Carnitine into the epididymal duct to promote sperm maturation. With the accumulation of information on OCTN2 in the human epididymis, OCTN2 will become a new molecular target for researches on male contraception.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Gene Expression Regulation
/
Contraception
/
Reverse Transcriptase Polymerase Chain Reaction
/
Gene Expression Profiling
/
Organic Cation Transport Proteins
/
Epididymis
/
Solute Carrier Family 22 Member 5
/
Genetics
/
Metabolism
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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