Grape seed extract inhibits the growth of prostate cancer PC-3 cells / 中华男科学杂志
National Journal of Andrology
;
(12): 331-333, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-319258
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the inhibitory effect of grape seed extract (GSE) on the growth of prostate cancer PC-3 cells.</p><p><b>METHODS</b>PC-3 cells were treated with GSE at the concentration of 100, 200 and 300 microg/ml for 24, 48 and 72 hours, respectively. The the inhibitory effect of GSE on the growth of the PC-3 cells and the kidney cells of SD rats was determined by MTT reduction assay, with primarily cultured kidney cells of 1-3 days old SD rats as the normal control.</p><p><b>RESULTS</b>GSE significantly inhibited the growth of PC-3 cells in a concentration- and time-dependent manner, but had only a mild inhibitory effect on the kidney cells.</p><p><b>CONCLUSION</b>GSE inhibits the growth of prostate cancer PC-3 cells and can be used as a new drug for the treatment of prostate cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Prostatic Neoplasms
/
Seeds
/
Time Factors
/
Plant Extracts
/
Cell Survival
/
Cells, Cultured
/
Chemistry
/
Rats, Sprague-Dawley
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
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