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Grape seed extract inhibits the growth of prostate cancer PC-3 cells / 中华男科学杂志
National Journal of Andrology ; (12): 331-333, 2008.
Article in Chinese | WPRIM | ID: wpr-319258
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the inhibitory effect of grape seed extract (GSE) on the growth of prostate cancer PC-3 cells.</p><p><b>METHODS</b>PC-3 cells were treated with GSE at the concentration of 100, 200 and 300 microg/ml for 24, 48 and 72 hours, respectively. The the inhibitory effect of GSE on the growth of the PC-3 cells and the kidney cells of SD rats was determined by MTT reduction assay, with primarily cultured kidney cells of 1-3 days old SD rats as the normal control.</p><p><b>RESULTS</b>GSE significantly inhibited the growth of PC-3 cells in a concentration- and time-dependent manner, but had only a mild inhibitory effect on the kidney cells.</p><p><b>CONCLUSION</b>GSE inhibits the growth of prostate cancer PC-3 cells and can be used as a new drug for the treatment of prostate cancer.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Prostatic Neoplasms / Seeds / Time Factors / Plant Extracts / Cell Survival / Cells, Cultured / Chemistry / Rats, Sprague-Dawley Limits: Animals / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Prostatic Neoplasms / Seeds / Time Factors / Plant Extracts / Cell Survival / Cells, Cultured / Chemistry / Rats, Sprague-Dawley Limits: Animals / Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2008 Type: Article