A novel class of testis-specific small RNAs: piRNAs / 中华男科学杂志
National Journal of Andrology
;
(12): 163-165, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-319271
ABSTRACT
Eukaryotes produce various types of 19-30 nt small RNAs, which act as guides to the regulation of gene expressions, such as mRNA degradation and translational repression. The Argonaute family members related to small RNA functions fall into 2 subfamilies. One is the AGO subfamily, whose 4 members distribute widely, confirmedly bind to miRNAs and siRNAs and inhibit the expression of target mRNAs through a pathway like RNA interference. The other is the PIWI subfamily, including PIWI, Aubgine (AUB) and AGO3, exclusively expressed in the testis. Recently, four research groups have isolated a new class of small RNAs from the mammalian testis, which interacts with the PIWI subfamily, hence named piwi-interfering RNAs (piRNAs), and is suggestive of an important role in spermatogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spermatogenesis
/
Testis
/
Classification
/
MicroRNAs
/
RNA, Small Interfering
/
RNA Interference
/
Genetics
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS