Expression of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers
Journal of the Korean Society of Coloproctology
;
: 337-344, 2008.
Article
in Korean
| WPRIM
| ID: wpr-31931
ABSTRACT
PURPOSE:
Angiogenesis is one of the key steps in solid tumor growth and metastasis. We investigated the prognostic significance of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1alpha (HIF-1alpha) expressions as markers of angiogenesis in colon cancer.METHODS:
We retrospectively reviewed the medical records of 78 patients with colon or rectal cancer who underwent a surgical resection at Soonchunhyang University Hospital from January 2000 to December 2001, and we evaluated the expression of VEGF and HIF-1alpha in archival tumor tissues by using immunohistochemistry. We recorded the clinical and the pathological characteristics of the patients and analyzed their survival outcomes.RESULTS:
Thirty-four (34) patients were male, and the mean age of all the patients was 66.7 years. HIF-1alpha and VEGF were positive in 56% (44 patients) and 53% (42 patients) of the tumors, respectively. HIF-1alpha expression was significantly associated with several pathological parameters, such as TNM stage (P=0.001), lymph node metastasis (P=0.001). HIF-1alpha expression was also associated with VEGF expression (P=0.032). The survival of patients with HIF-1alpha expression was worse than that of patients with no HIF-1alpha expression (P=0.036). However, VEGF expression was not associated with other pathological characteristics.CONCLUSIONS:
We suggest that, in cases of colorectal cancer, HIF-1alpha expression may be associated with expression of VEGF, progression of tumors, and poor prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Rectal Neoplasms
/
Immunohistochemistry
/
Colorectal Neoplasms
/
Biomarkers, Tumor
/
Medical Records
/
Retrospective Studies
/
Colon
/
Colonic Neoplasms
/
Vascular Endothelial Growth Factor A
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Coloproctology
Year:
2008
Type:
Article
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