The roles of carbon monoxide on hypoxic pulmonary vasoconstriction / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 261-263, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-319313
ABSTRACT
<p><b>AIM AND METHODS</b>To study the roles of carbon monoxide on hypoxic pulmonary vasoconstriction (HPV) by investigating the effects of exogenous carbon monoxide and heme oxygenase inhibitor ZnPPIX on hypoxic vasoconstriction reaction of isolated rat pulmonary arterial rings (PAR).</p><p><b>RESULTS</b>Hypoxia caused constriction in PAR preconstricted by PE. Both ZnPPIX and carbon monoxide inhibited hypoxic pulmonary constriction significantly by increasing the cGMP level after hypoxia.</p><p><b>CONCLUSION</b>ZnPPIX and exogenous carbon monoxide can inhibit HPV. The reduction of cGMP induced by the decreased of CO may be one of reasons of HPV.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Pulmonary Artery
/
Vasoconstriction
/
In Vitro Techniques
/
Carbon Monoxide
/
Rats, Wistar
/
Hypoxia
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article
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