TGF-beta and HSP70 expression in human skin fibroblasts after ultraviolet B irradiation / 中国应用生理学杂志

ABSTRACT

<p><b>AIM AND METHODS</b>For further understanding the signal transduction pathway of the inducible HSP70 expression the expression of TGF-betamRNA and HSP70 in fibroblasts after 5, 10 and 20 mJ/cm2 of UVB irradiation, and the content of TGF-beta protein in culture supernatants and HSP70 expression in fibroblasts by 10mJ/cm2 UVB irradiation after preincubation with the anti-human TGF-beta receptor II antibody were observed.</p><p><b>RESULTS</b>(1) TGF-betamRNA expression positively correlated with HSP70 expression in UVB irradiation of different doses (r = 0. 906). (2) TGF-beta content in the culture supernatants negatively correlated with the HSP70 expression induced in adding anti-human TGF-beta receptor II antibody and UVB treatment condition (r = - 0.995).</p><p><b>CONCLUSION</b>TheTGF-beta play an important action in HSP70 inducing by UVB irradiation.</p>