Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 155-158, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-319350
ABSTRACT
<p><b>AIM AND METHODS</b>To observe the effects of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig.</p><p><b>METHODS</b>Using inside-out configuration of patch-clamp single channel recording technique.</p><p><b>RESULTS</b>Puerarin 20 micromol/L, 40 micromol/L, 80 microml/L could inhibit the open-close rate of K+ channel of isolated ventricular myocyte in guinea pig. At 80 micromol/L, Po was decreased from 0.867 +/- 0.13 to 0.019 +/- 0.01 (n = 5, P < 0.05).</p><p><b>CONCLUSION</b>Puerarin can inhibit K+ channel of isolated ventricular myocyte in guinea pig. It may be the mechanism of Puerarin against arrhythmias in molecular level.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Potassium Channels
/
Patch-Clamp Techniques
/
Cell Biology
/
Myocytes, Cardiac
/
Guinea Pigs
/
Heart Ventricles
/
Isoflavones
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article
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