The research on monoamine neurotransmitters changes in plasma and cerebrospinal fluid in patients with persistent vegetative state / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 136-138, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-319357
ABSTRACT
<p><b>AIM</b>To study the relationships between the pathogenesis of persistent vegetative state (PVS) and the levels of monoamine neurotransmitters in plasmas and cerebrospinal fluids (CSFs) in patients with PVS.</p><p><b>METHODS</b>The high-pressure liquid chromatography (HPLC) was used to detect.</p><p><b>RESULTS</b>It was found that the level of dopamine (1.95 +/- 0.99) was significantly increased in plasma compared with the control (1.16 +/- 0.47) (P < 0.05), but the levels of 5-HT, TYR, TRP, GABA of plasma were insignificantly changed. In cerebrospinal fluid, the level of DA was insignificantly changed, and the level of 5-HT (0.49 +/- 0.32) was significantly decreased compared with the control (1.02 +/- 0.35) (P < 0.05), but the levels of TYR (1.36 +/- 0.11), TRP (0.63 +/- 0.40), GABA (1.15 +/- 0.61) were significantly increased respectively compared with the controls (0.40 +/- 0.24; 0.29 +/- 0.22; 0.37 +/- 0.45) (P < 0.05; P < 0.05; P < 0.01). The levels of GABA and DA in plasma were significant correlated (P < 0.05), and GABA and DA in CSF were also significant correlated (P < 0.01).</p><p><b>CONCLUSION</b>The results of this study suggested that PVS is related to the decrease of 5-HT in CSF and the increase of DA in plasma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Biogenic Monoamines
/
Case-Control Studies
/
Cerebrospinal Fluid
/
Persistent Vegetative State
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS