Neuropathologic investigation of area tempestas sclerosis in epileptic sensitive rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 84-87, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-319373
ABSTRACT
<p><b>AIM AND METHODS</b>The relation between AT sclerosis (loss of neurons and proliferation of astrocytes) and long-lasting epileptic susceptibility was investigated by thionine staining, GFAP immunohistochemistry and observing the behavior of rats, after scorpion venom (SV) or normal saline (NS) administrated for three week.</p><p><b>RESULTS</b>Compared with NS+ NS group, both the loss of neurons and proliferation of astrocytes were very marked in KA+ NS group (epileptic susceptible rats) (P < 0.05), but those changes were not visible in KA+ NS group (epileptic nonsusceptible rats).</p><p><b>CONCLUSIONS</b>It suggested that AT sclerosis may be one of important reasons of the long-lasting epileptic susceptibility.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Astrocytes
/
Rats, Sprague-Dawley
/
Epilepsy
/
Glial Fibrillary Acidic Protein
/
Metabolism
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article
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