Relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents in cultured hypothalamic cells / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 30-33, 2002.
Article
in Zh
| WPRIM
| ID: wpr-319388
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the relationship between enhanced anoxic tolerance induced by hypoxic preconditioning and Na+, K+ currents.</p><p><b>METHODS</b>After hypoxic preconditioning and acute anoxia the I(Na), I(K) were measured in cultured hypothalamic cells by patch-clamp whole cell recording technique.</p><p><b>RESULTS</b>The amplification of Na+ currents did not been significantly changed, but the amplification of K+ currents was in hypoxic preconditioning neurons; acute anoxia lead to the inhibition of Na+, K+ currents in the two groups, while Na+, K+ currents in non-preconditioned control group were inhibited severity than hypoxic preconditioning group.</p><p><b>CONCLUSION</b>It is presumed enhanced anoxia tolerance induced by hypoxic preconditioning may be related to the opening of K+ channels.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oxygen
/
Physiology
/
Potassium
/
Sodium
/
Cell Hypoxia
/
Cells, Cultured
/
Rats, Wistar
/
Patch-Clamp Techniques
/
Cell Biology
/
Hypothalamus
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2002
Type:
Article