Expression of pin1 in endometrial carcinoma and its relation with PR / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma.</p><p><b>METHODS</b>The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens.</p><p><b>RESULTS</b>Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression.</p><p><b>CONCLUSION</b>Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.</p>