Value of serum cystatin C level in assessing renal damage in preeclamptic patients / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the significance of the serum cystatin C (Cys-C) in assessing renal dysfunction in preeclamptic women.</p><p><b>METHODS</b>Ninety-six women with normal pregnancies and 48 with severe preeclampsia were examined for 24-hour creatinine clearance (CrCl), serum creatinine (Scr), Cys-C, uric acid (UA) and beta microglobulin (MG) concentrations during the second and third trimesters and postpartum in severe preeclamptic patients. These indexes were analyzed to estimate the glomerular filtration rate.</p><p><b>RESULTS</b>The concentrations of Scr, UA and MG were significantly higher in the third trimester than in the second trimester in women with normal pregnancies, where serum Cys-C levels showed no significant variations. Severe preeclamptic patients exhibited significantly higher serum Cys-C levels in the third than in the second trimester. Correlation analyses demonstrated significant negative correlations between Cys-C and 24-hour CrCl in the second and third trimesters in all the 144 pregnant women and in the postpartum period in severe preeclamptic patients.</p><p><b>CONCLUSION</b>Serum Cys-C can serve as a good indicator for assessing renal function in severe preeclamptic women from antepartum to postpartum periods.</p>