Expression of angiopoietin-2 and vascular endothelial growth factor in human colon cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1236-1239, 2013.
Article
in Zh
| WPRIM
| ID: wpr-319438
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the expressions of angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF) in colorectal cancer tissues with Dukes' clinicopathological features.</p><p><b>METHODS</b>Ang-2 and Tie-2 mRNA expressions were detected in colorectal cancer tissues, adjacent tissues, and normal tissues by real time-PCR. Quantikine immunoassays were used to measure the protein expressions of Ang-2 and VEGF in the tissues and serum samples.</p><p><b>RESULTS</b>Ang-2 and Tie-2 levels were significantly higher in the serum of the patients than in the normal tissues (P<0.05), and their expressions were strongly correlated (r=0.879, P=0.000). Tumor tissue Ang-2 and VEGF levels were significantly higher than their levels in the adjacent and normal tissues (P<0.05). In colorectal cancer patients, the peripheral blood level of Ang-2 was significantly higher than that in healthy control subjects, and comparable with that in mesenteric blood (P>0.05). In Dukes' stage C and D patients, serum Ang-2 and VEGF levels were significantly higher than those in patients in Dukes' stage A and B (P<0.05).</p><p><b>CONCLUSION</b>Ang-2 and VEGF over expressions may play an important role in the occurrence and progression of colorectal cancer.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Blood
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Colorectal Neoplasms
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Case-Control Studies
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Gene Expression Regulation, Neoplastic
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Angiopoietin-2
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Vascular Endothelial Growth Factor A
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Metabolism
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Neovascularization, Pathologic
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2013
Type:
Article