F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients
Experimental & Molecular Medicine
;
: 29-31, 2001.
Article
in English
| WPRIM
| ID: wpr-31945
ABSTRACT
Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between lung cancer and the mutations of CFTR gene, we determined amino acid sequences using reverse transcription-polymerase chain reaction (RT-PCR) and DNA sequencing. In this study, the deletion mutation of 508th amino acid in one of nine lung caner patients was found confirming that CFTR gene mutation exists in a Korean lung cancer patient.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sequence Deletion
/
Cystic Fibrosis Transmembrane Conductance Regulator
/
Korea
/
Lung Neoplasms
/
Middle Aged
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2001
Type:
Article
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