Establishment of a scoring system for predicting the positive rate of prostatic biopsy for prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 53-56, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-319542
ABSTRACT
<p><b>OBJECTIVE</b>To identify the predictors of the positive results of transrectal ultrasound (TRUS)-guided biopsy for prostate cancer.</p><p><b>METHODS</b>We performed univariate and multivariate logistic regression analyses on the relevant data on 385 male patients that underwent TRUS-guided biopsy for prostate cancer, including such potential predictors as age, body mass index (BMI), symptoms, results of digital rectal examination (DRE), tPSA, fPSA, free/total PSA ratio (f/tPSA), prostate volume (PV), and PSA density (PSAD) for identification of the risk factors related to the positive rate of biopsy. Then we constructed a scoring system as a tool for predicting prostate cancer in repeat biopsies and determined the sensitivity of the system by calculating the false positive rate using the receiver operating characteristic curve.</p><p><b>RESULTS</b>Among the 385 patients, 139 (36.1%) were diagnosed with prostate cancer. On multivariate analysis, age (P < 0.01), DRE (P < 0.01), tPSA (P < 0.01), fPSA (P < 0.01), f/tPSA (P < 0.01), PV (P < 0.01), and PSAD (P < 0.01) were all significant predictors of prostate cancer. Multivariate logistic regression analysis showed age, tPSA, f/tPSA, PV, and PSAD to be independent predictors, with ORs and 95% CIs of 1.07 (1.05-1.16), 1.05 (1.02-1.15), 0.97 (0.86-0.99), 0.98 (0.87-0.96), and 1.79 (1.48-2.06), respectively. Moreover, patients with the risk score of 3-5 had a significantly higher rate of prostate cancer than those with 0-2 (64% vs 11%, P < 0.001).</p><p><b>CONCLUSION</b>The scoring system on the key predictors of prostate cancer can help urologists to identify the men in need of prostatic biopsy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostate
/
Prostatic Neoplasms
/
Logistic Models
/
Chemistry
/
Risk Factors
/
ROC Curve
/
Prostate-Specific Antigen
/
Ultrasonography, Interventional
/
Digital Rectal Examination
Type of study:
Etiology study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2015
Type:
Article
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