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Determination of dissolution of liuwei dihuang concentrated pills based on multi-index components / 中国中药杂志
Article in Zh | WPRIM | ID: wpr-319622
Responsible library: WPRO
ABSTRACT
With the content of gallic acid, loganin, paeoniflorin and paeonol as the indexes, to screen out dissolution determination conditions, establish the dissolution determination method for multi-index components in Liuwei Dihuang concentrated pills, calculate and map the accumulative dissolution curve, and then compare the dissolution of products from different pharmaceutical factories through the similarity factor (f2). According to the results, the optimum dissolution determination conditions were the paddle method, with 250 mL 0.1 mol x L(-1) hydrochloric acid as the dissolution medium, and a rotation rate of 100 r x min(-1). The similarity factor values (f2) of the dissolution curves of the four main components of Liuwei Dihuang concentrated pills from different pharmaceutical factories were mostly less than 50. This demonstrated a significant difference in the dissolution of Liuwei Dihuang concentrated pills from different pharmaceutical factories, and provided scientific basis for improving the equality evaluation of Liuwei Dihuang concentrated pills.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Organic Chemicals / Quality Control / Solvents / Drugs, Chinese Herbal / Chemistry Limits: Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article
Full text: 1 Index: WPRIM Main subject: Organic Chemicals / Quality Control / Solvents / Drugs, Chinese Herbal / Chemistry Limits: Humans Language: Zh Journal: China Journal of Chinese Materia Medica Year: 2014 Type: Article