Effect of tissue factor in extravascular migration of fibrosarcoma cells / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 184-188, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-319812
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of tissue factor (TF) in extravascular migration of fibrosarcoma cells and hematogenous metastasis.</p><p><b>METHODS</b>The expression of tissue factor in fibrosarcoma HT1080 cells was analyzed by flow cytometry. The extravascular migration of fibrosarcoma cells was observed in a constructed monolayer vascular endothelial cells and extra-cellular matrix model.</p><p><b>RESULT</b>Tissue factor was highly expressed in HT1080 cells. HT1080 migrated and passed through the monolayer vascular endothelial cells to the collagen gel in a time-dependent manner. Anti-TF antibody inhibited extravascular migration of fibrosarcoma cells and the inhibition was concentration-dependent (P<0.05).</p><p><b>CONCLUSION</b>Tissue factor may enhance hematogenous metastasis through extravascular migration of fibrosarcoma cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Thromboplastin
/
Cell Movement
/
Cells, Cultured
/
Endothelial Cells
/
Fibrosarcoma
/
Metabolism
/
Neoplasm Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2011
Type:
Article
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