Protective effect of intranasal cilostazol administration on chronic injury after cerebral ischemia in mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 169-175, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-319814
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective effect of cilostazol administrated intranasally on chronic injury after focal cerebral ischemia in mice.</p><p><b>METHODS</b>Focal cerebral ischemia in mice was induced by middle cerebral artery occlusion (MCAO). Cilostazol was administrated intranasally or intraperitoneally 1 h, 4 h and 7 h after the operation; then twice a day from the second day for 2 weeks. The neurological deficit scoring and the inclined board testing were performed within 35 d after ischemia. The survival rate, infarct volume and neuron density were assessed 35 d after ischemia.</p><p><b>RESULT</b>Intranasal cilostazol at 0.3 mg/kg increased the survival rate. Intranasal cilostazol (0.3 mg/kg, 1 mg/kg) and intraperitoneal cilostazol (10 mg/kg) significantly attenuated neurological deficit, reduced infarct volume, and increased the survival neuron density in the border of ischemia region.</p><p><b>CONCLUSION</b>Cilostazol administered intranasally demonstrates protective effects on chronic cerebral ischemia in mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Tetrazoles
/
Brain
/
Administration, Intranasal
/
Brain Ischemia
/
Infarction, Middle Cerebral Artery
/
Therapeutic Uses
/
Disease Models, Animal
/
Drug Therapy
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2011
Type:
Article
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