Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 145-149, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-319818
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the role of water channel AQP4 in NMDA-induced brain injury in mice.</p><p><b>METHODS</b>In AQP4 gene knockout (AQP4(-/-)) mice, brain injury was induced by microinjection of NMDA into the cortex. The injured area was determined by toluidine blue staining, degenerated neurons were detected by Fluro-Jade B staining, and increased blood-brain barrier (BBB) permeability was evaluated by IgG immunostaining.</p><p><b>RESULT</b>Compared with wild-type mice, AQP4(-/-) mice exhibited increased cortical lesion area, aggravated neuron degeneration, and increased BBB disruption after NMDA microinjection.</p><p><b>CONCLUSION</b>AQP4 may play a protective role in NMDA-induced brain injury in mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Brain
/
Blood-Brain Barrier
/
N-Methylaspartate
/
Mice, Knockout
/
Aquaporin 4
/
Toxicity
/
Genetics
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2011
Type:
Article
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