Research advances on hydrogen therapy in nervous system diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 638-643, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319845
ABSTRACT
Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Hydroxyl Radical
/
Oxidative Stress
/
Peroxynitrous Acid
/
Drug Therapy
/
Hydrogen
/
Metabolism
/
Nervous System
/
Nervous System Diseases
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
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