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Research advances on hydrogen therapy in nervous system diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 638-643, 2010.
Article in Chinese | WPRIM | ID: wpr-319845
ABSTRACT
Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Hydroxyl Radical / Oxidative Stress / Peroxynitrous Acid / Drug Therapy / Hydrogen / Metabolism / Nervous System / Nervous System Diseases Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Hydroxyl Radical / Oxidative Stress / Peroxynitrous Acid / Drug Therapy / Hydrogen / Metabolism / Nervous System / Nervous System Diseases Limits: Humans Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article