Effect of long-term highly active antiretroviral therapy on abnormal immune activation and immune reconstruction in HIV-1 infected individuals / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 618-622, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319849
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of long-term highly active antiretroviral therapy (HAART) on the abnormal activation state and immune reconstitution in HIV-1 infected individuals.</p><p><b>METHODS</b>CD4(+)T, CD8(+)T, CD8(+) CD38(+)T, CD8(+)HLADR(+)T and NK cell counts in the peripheral blood of 55 cases of HIV-1 infected individuals were measured by flow cytometry before and after HAART, and 30 healthy individuals served as controls.</p><p><b>RESULT</b>Compared to healthy individuals, the CD4(+)T and NK cells decreased (P < 0.05) and CD8(+)T and CD8(+)HLADR(+)T cells increased significantly (P < 0.05) in HIV-1 infected individuals before HAART. After HAART, CD4(+)T and NK cells were recovered (P < 0.05), but still lower than normal (P < 0.05); CD4(+)T cell count in HIV-1 infected individuals remained stable at 1, 3 and 5 years after treatment, there were no significant differences among each groups; NK cell count had a downward trend with HAART (P < 0.05), there were statistical differences between 1-year and 5-year-HAART groups(P < 0.05). CD8(+)HLADR(+)T cells decreased promptly (P < 0.05), there were statistical differences between before and after HAART groups, 1-year and 5-year, 3-year and 5-year HAART groups (P < 0.05). CD8(+)CD38(+)T cells declined slowly, with no statistical differences amont each groups.</p><p><b>CONCLUSION</b>HAART can effectively reduce abnormal immune activation in HIV-1 infected individuals and achieve immune reconstitution to a certain degree.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Lymphocyte Activation
/
T-Lymphocytes
/
Case-Control Studies
/
HIV Infections
/
Follow-Up Studies
/
HIV-1
/
Viral Load
/
Antiretroviral Therapy, Highly Active
/
Drug Therapy
/
Allergy and Immunology
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
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