Research advances of inflammasome and its role in sepsis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 487-492, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319871
ABSTRACT
Inflammasomes are high-molecular-weight, multiprotein complexes in cells, which are assembled after cytoplasmic nucleotide-binding oligomerization domain like receptors (NLRs) sense pathogens and danger signals. The inflammasome can activate caspase-1, and later makes the pro-IL-1β, proIL-18 precursor mature by cleavaging, thereby mediates the innate immunity. Dysregulation of inflammasomes plays an important role in the development of sepsis and other immune inflammatory diseases, thus inflammasome may be a new target for prevention and treatment of sepsis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Chemistry
/
Sepsis
/
Caspase 1
/
Interleukin-18
/
Allergy and Immunology
/
Interleukin-1beta
/
Inflammasomes
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
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