Early high-volume hemofiltration treatment in severe sepsis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 483-486, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319872
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of early application of high-volume hemofiltration treatment (HVHF) on the levels of lactic acid, pro-inflammatory cytokines and C-reactive protein (CRP) in plasma, as well as APACHE II score in patients suffering from severe sepsis.</p><p><b>METHODS</b>Thirty patients meeting the diagnosis of severe sepsis were enrolled in the trial within 24 hours of insults. The level of lactic acid, interleukin-6 (IL-6) and CRP in plasma were measured before HVHF and at 24, 48 or 72 h following HVHF treatment.</p><p><b>RESULT</b>The plasma levels of lactic acid and IL-6 decreased significantly at 24 h, 48 h, 72 h after HVHF (P <0.05), while, IL-10 did not differ significantly following HVHF (P>0.05), when compared with that before HVHF.</p><p><b>CONCLUSION</b>The early application of HVHF could clear the plasma lactic acid and pro-inflammatory cytokines, and improve the tissue oxygenation in severe sepsis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Blood
/
C-Reactive Protein
/
Hemofiltration
/
Interleukin-6
/
Treatment Outcome
/
Interleukin-10
/
Sepsis
/
APACHE
/
Lactic Acid
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
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