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Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences ; (6): 454-457, 2010.
Article in Chinese | WPRIM | ID: wpr-319877
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of hydrogen gas inhalation on survival rate and serum high mobility group box 1 (HMGB1) levels in severe septic mice.</p><p><b>METHODS</b>Severe sepsis was induced by cecal ligation and puncture (CLP) operation in mice.A total of 248 mice were randomly divided into four groups sham operation group (sham), sham operation with hydrogen gas inhalation group (sham+H2), severe CLP group (severe CLP) and severe CLP with hydrogen gas inhalation group (severe CLP+H2). Hydrogen gas inhalation was given for 1 h at 1st and 6th h after CLP or sham operation, respectively. The survival rates and serum HMGB1 levels of all groups at different time points were measured.</p><p><b>RESULT</b>The 7-d survival rates of severe CLP mice was 0 % (Compared with Sham group, P <0.05), and the serum HMBG1 levels from h2 to h32 after CLP operation were significantly increased in severe CLP mice (Compared with Sham group, P <0.05). Hydrogen gas treatment increased the 7-d survival rate of severe CLP mice to 60 % (Compared with severe sepsis group, P <0.05) and significantly reduced the serum HMGB1 levels at different time points (Compared with severe sepsis group, P <0.05).</p><p><b>CONCLUSION</b>Hydrogen gas inhalation can decrease the serum HMGB1 levels and increase the survival rate of rats with severe sepsis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Administration, Inhalation / Sepsis / HMGB1 Protein / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Hydrogen / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Administration, Inhalation / Sepsis / HMGB1 Protein / Therapeutic Uses / Disease Models, Animal / Drug Therapy / Hydrogen / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2010 Type: Article