Role of immunologic abnormality in recurrent parotitis in children / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the relationship between immune function and the recurrent parotitis (RP) for children.</p><p><b>METHODS</b>The children diagnosed as RP were divided into two groups aged under 6y and over 6y and the immune function were measured and compared with that of normal children.</p><p><b>RESULTS</b>For RP children the ratio of CD4+ T cell in over 6y group was significantly lower than that in under 6y group (P<0.05), while IgG value in over 6y group was higher than that in under 6y group (P<0.05). Compared with normal children, RP children in under 6y group had higher CD8+ T cell ratio and IgG, IgE, IgA and C3 value (P<0.01) and lower CD4+ T cell ratio (P<0.01), while RP children over 6y group, they had higher CD8+ T cell ratio, IgE value (P<0.01) and C3 (P<0.05), lower CD4<T cell ratio than those in control group (P<0.01). IgE value and CD8+ T cell ratio in under 6y group were higher than those over 6y control group (P<0.01).</p><p><b>CONCLUSION</b>Impaired immune function may play an important role in the recurrent parotitis in children.</p>