Serum metalloproteinase-3 levels in assessing efficacy of Etanercept in patients with ankylosing spondylitis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 409-414, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319885
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the value of metalloproteinase-3 (MMP-3) levels in assessing efficacy of etanercept treatment in patients with ankylosing spondylitis (AS).</p><p><b>METHODS</b>The serum and synovial fluid levels of MMP-3 were measured by enzyme linked immunosorbent assay (ELISA) in 48 patients with AS in week 0, 6 and 12; and also measured in 30 serum samples and 10 synovial fluid samples from healthy controls.</p><p><b>RESULTS</b>The serum levels of MMP-3 in AS patients were significantly higher than those in controls. In AS patients, the MMP-3 levels in synovial fluid were significantly higher than those in serum levels. The serum MMP-3 levels in AS patients with peripheral arthritis were higher than those with exclusively axial involvement; while C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) did not differ between these 2 groups of AS. At week 6 and week 12 of etanercept treatment, the serum MMP-3 levels were significantly decreased (p<0.01) with the declining trend of ESR, CRP, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) (all p<0.01). Before the etanercept treatment (week 0), serum levels of MMP-3 were correlated with ESR, CRP, BASDAI and BASFI (p<0.05). ESR was also correlated with CRP and BASFI, but not with BASDAI (r=0.361, P=0.071). At weeks 12, serum MMP-3 levels were still correlated with ESR, CRP and BASDAI (P<0.05), but not with BASFI (P=0.339); ESR was correlated with CRP, but not with BASDAI and BASFI. There was a significant correlation between BASDAI and BASFI (r=0.818,P=0.001).</p><p><b>CONCLUSION</b>Serum MMP-3 levels are closely related to disease activity and may serve as an useful indicator for efficacy of etanercept treatment in AS patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spondylitis, Ankylosing
/
Blood
/
Immunoglobulin G
/
Biomarkers
/
Receptors, Tumor Necrosis Factor
/
Antirheumatic Agents
/
Matrix Metalloproteinase 3
/
Therapeutic Uses
/
Drug Therapy
/
Etanercept
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS