Expression of B7-H4 in prostate cancer and its clinical significance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 345-349, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-319896
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of B7-H4 in prostate cancer tissue and the relationship between the expression and the clinicopathological features.</p><p><b>METHODS</b>Immunohistochemical staining was used to detect the expression of B7-H4 in prostate cancer tissue. And the relationship between the expressions and pathology was evaluated.</p><p><b>RESULTS</b>The B7-H4 was diffusely expressed in cytoplasm and/or membrane of the prostate cancer tissue; the expression was much higher than that in normal prostate tissue (P<0.05). The expression of B7-H4 in the prostate cancer tissue was higher in patients with higher tumor grade.</p><p><b>CONCLUSION</b>B7-H4 may be used as an new indicator for the diagnosis and prognosis of prostate cancer and a novel target for immunotherapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostate
/
Prostatic Neoplasms
/
Biomarkers, Tumor
/
B7-1 Antigen
/
V-Set Domain-Containing T-Cell Activation Inhibitor 1
/
Metabolism
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2010
Type:
Article
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