Study on the regulation of autophagy against anticancer drugs' toxicity / 药学学报
Acta Pharmaceutica Sinica
; (12): 29-32, 2016.
Article
in Zh
| WPRIM
| ID: wpr-320021
Responsible library:
WPRO
ABSTRACT
Autophagy is a crucial biological process in eukaryotes, which is involved in cell growth, survival and energy metabolism. It has been confirmed that autophagy mediates toxicity of anticancer drugs, especially in heart, liver and neuron. It is important to understand the function and mechanism of autophagy in anticancer drugs-induced toxicity. Given that autophagy is a double-edged sword in the maintenance of the function of heart, liver and neuron, the autophagy-mediated toxicity are very complicated in the body. We provide a review on the concept of autophagy and current status about autophagy-mediated toxicity of anticancer drugs. The knowledge is crucial in the basic study of anticancer drugs-induced toxicity, and provides some strategies for the development of alleviating the toxicity of anticancer drugs.
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Autophagy
/
Drug Therapy
/
Toxicity
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
Zh
Journal:
Acta Pharmaceutica Sinica
Year:
2016
Type:
Article