Determination of contact angle of pharmaceutical excipients and regulating effect of surfactants on their wettability / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1342-1345, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-320079
ABSTRACT
To study the effects of surfactants on wettability of excipients, the contact angles of six types of surfactants on the surface of two common excipients and mixture of three surfactants with excipients were measured using hypsometry method. The results demonstrated that contact angle of water on the surface of excipients was associated with hydrophilcity of excipients. Contact angle was lowered with increase in hydrophilic groups of excipient molecules. The sequence of contact angle from small to large was starch < sodium benzoate < polyvinylpyrrolidone < sodium carboxymethylcellulose < sodium alginate < chitosan < hydroxypropyl methyl cellulose <magnesium stearate. In addition, surfactants both in droplets and mixed in excipients significantly reduced the contact angle of excipients, and their abilities to lower contact angle varied. The results of the present study offer a guideline in the formulation design of tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Surface-Active Agents
/
Tablets
/
Water
/
Chemistry
/
Chemistry, Pharmaceutical
/
Wettability
/
Excipients
/
Hydrophobic and Hydrophilic Interactions
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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