Advances in the study of site-specific antibody-drug conjugates / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1225-1231, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-320097
ABSTRACT
Antibody drug conjugates (ADCs) are an emerging class of targeted therapeutics with the potential to improve therapeutic index over the traditional chemotherapy. However, it is difficult to control the site and stoichiometry of conjugation in mAb, typically resulting in heterogeneous mixtures of ADCs that are difficult to optimize. New methods for site-specific drug attachment allow development of more homogeneous conjugates and control of the site of drug attachment. In this article, the new literature on development of ADCs and site-specific ADCs is reviewed. In addition, we summarized the various strategies in production of site-specific ADCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Binding Sites, Antibody
/
Chemistry
/
Immunoconjugates
/
Antibodies, Monoclonal
/
Antibody Specificity
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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