Current applications of dexamethasone for cancer treatment / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1217-1224, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-320098
ABSTRACT
Dexamethasone is a synthetic glucocorticoid that is widely used in clinical due to its multiple pharmacological effects. Recently, dexamethasone is increasingly utilized in anti-cancer therapy. It is frequently used to prevent side effects of chemotherapy such as nausea, vomiting and pain, as well as to increase the anti-tumor activity of the cancer chemotherapeutic agents as a chemosensitizer and to inhibit tumor growth as an anti-cancer agent in some certain cancers. Dexamethasone produces the effects in anti-inflammation, anti-angiogenesis, control of estrogen activity and so on, by binding to glucocorticoid receptor to regulate gene expression of some important bio-signal molecules. Those signal pathways could interfere with the transcription of various factors which can regulate proliferation, invasion and metastasis of tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vomiting
/
Dexamethasone
/
Signal Transduction
/
Therapeutic Uses
/
Drug Therapy
/
Antiemetics
/
Nausea
/
Neoplasms
/
Antineoplastic Agents
Limits:
Humans
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2015
Type:
Article
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