Single and combined effects of estrone and 17β-estradiol on male goldfish / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 176-184, 2013.
Article
in English
| WPRIM
| ID: wpr-320353
ABSTRACT
<p><b>OBJECTIVE</b>To assess the single and combined effects of estrone (E1) and 17β-estradiol (E2) on goldfish (Carassius auratus).</p><p><b>METHODS</b>Batch tests were conducted. Serum levels of vitellogenin (VTG) and E2, gonadosomatic indices (GSI), gonadal DNA damage and liver 7-ethoxyresorufin-O-deethylase (EROD) activity were measured after exposure for 14 days.</p><p><b>RESULTS</b>The VTG level increased significantly in a concentration-dependent manner. The serum E2 level was significantly higher and the GSI level was significantly lower in goldfish after exposed to the 3 drugs. DNA damage occurred in treated samples and EROD activity was significantly suppressed 7 days after exposure. The joint effect of E1 and E2 was additive with regard to VTG induction.</p><p><b>CONCLUSION</b>The results of our study highlight a series of effects of steroidal estrogens on goldfish. Further study is needed to confirm their effect as a whole.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Blood
/
DNA Damage
/
Goldfish
/
Vitellogenins
/
Cytochrome P-450 CYP1A1
/
Drug Combinations
/
Estradiol
/
Estrone
/
Gonads
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2013
Type:
Article
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