Compared Markov with fractal models by using single-channel experimental and simulation data / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 923-928, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-320451
ABSTRACT
The gating mechanical kinetical of ion channels has been modeled as a Markov process. In these models it is assumed that the channel protein has a small number of discrete conformational states and kinetic rate constants connecting these states are constant, the transition rate constants among the states is independent both of time and of the previous channel activity. It is assumed in Liebovitch's fractal model that the channel exists in an infinite number of energy states, consequently, transitions from one conductance state to another would be governed by a continuum of rate constants. In this paper, a statistical comparison is presented of Markov and fractal models of ion channel gating, the analysis is based on single-channel data from ion channel voltage-dependence K+ single channel of neuron cell and simulation data from three-states Markov model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Computer Simulation
/
Potassium Channels
/
Ion Channel Gating
/
Cells, Cultured
/
Markov Chains
/
Rats, Sprague-Dawley
/
Fractals
/
Patch-Clamp Techniques
/
Electrophysiology
Type of study:
Health economic evaluation
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2006
Type:
Article
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