Ras-MAPK signaling pathway activated via brain-derived neurotrophic factor / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 915-918, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-320453
ABSTRACT
Brain-derived neurotrophic factor (BDNF)is the richest neurophin in brain tissue and may act as an activity-dependent neuronal survival factor. In vitro, BDNF plays an important role in preventing cortical neurons from hypoxia-induced neurotoxicity. It could induce a variety of cellular responses such as cell growth, survival, differentiation, and anti-apoptosis mainly via activating mitogen-activated protein kinase (MAPK) and Ca2+/calmodulin-dependent kinase (CaMK) signaling pathways. And among these multiple signaling pathways there is growing evidence of complicated cross talk.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Signal Transduction
/
Cells, Cultured
/
Calcium-Calmodulin-Dependent Protein Kinases
/
Brain-Derived Neurotrophic Factor
/
Mitogen-Activated Protein Kinases
/
Cell Biology
/
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/
Neurons
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS