The reconstruction of bioengineer active corneal stroma and its biocompatibility study / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 878-881, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-320462
ABSTRACT
This paper aims to explore the biocompatibility of bioengineer active corneal stroma (BACS), as the biological carrier for cornea reconstruction, to provide the basis for future study on clinic application. The cells and immunogenic components of cornea stroma were removed through different extract methods. A complex of functional corneal stroma cells and acellular corneal stroma was used to reconstruct BACS. Their morphological characteristics and ultrastructures were observed with transmission electron microscope. The complex was grafted into interlamellar stromal pockets. Cells were labeled by BrdU to examine the survival and conversion after grafting. The cells could survive and proliferate in acellular corneal stroma. All the nuclei of the corneal stromal cells showed positive labeling with BrdU in the BACS. After 4 weeks, BACS became transparent; after 8 weeks, the bioengineer active cornea stroma was fully reconstructed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostheses and Implants
/
Prosthesis Design
/
Swine
/
Transplantation
/
Biocompatible Materials
/
Materials Testing
/
Corneal Stroma
/
Cell Biology
/
Tissue Engineering
/
Methods
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2006
Type:
Article
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