Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer / 癌症
Chinese Journal of Cancer
;
(12): 133-139, 2014.
Article
in English
| WPRIM
| ID: wpr-320529
ABSTRACT
This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Neoplastic Stem Cells
/
Bone Marrow Cells
/
Cell Fusion
/
Cell Biology
/
Hybrid Cells
/
Neoplasm Metastasis
/
Neoplasms
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2014
Type:
Article
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