A nomogram to predict Gleason sum upgrading of clinically diagnosed localized prostate cancer among Chinese patients / 癌症
Chinese Journal of Cancer
;
(12): 241-248, 2014.
Article
in English
| WPRIM
| ID: wpr-320532
ABSTRACT
Although several models have been developed to predict the probability of Gleason sum upgrading between biopsy and radical prostatectomy specimens, most of these models are restricted to prostate-specific antigen screening-detected prostate cancer. This study aimed to build a nomogram for the prediction of Gleason sum upgrading in clinically diagnosed prostate cancer. The study cohort comprised 269 Chinese prostate cancer patients who underwent prostate biopsy with a minimum of 10 cores and were subsequently treated with radical prostatectomy. Of all included patients, 220 (81.8%) were referred with clinical symptoms. The prostate-specific antigen level, primary and secondary biopsy Gleason scores, and clinical T category were used in a multivariate logistic regression model to predict the probability of Gleason sum upgrading. The developed nomogram was validated internally. Gleason sum upgrading was observed in 90 (33.5%) patients. Our nomogram showed a bootstrap-corrected concordance index of 0.789 and good calibration using 4 readily available variables. The nomogram also demonstrated satisfactory statistical performance for predicting significant upgrading. External validation of the nomogram published by Chun et al. in our cohort showed a marked discordance between the observed and predicted probabilities of Gleason sum upgrading. In summary, a new nomogram to predict Gleason sum upgrading in clinically diagnosed prostate cancer was developed, and it demonstrated good statistical performance upon internal validation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatectomy
/
Prostatic Neoplasms
/
Biopsy
/
Logistic Models
/
Cohort Studies
/
Prostate-Specific Antigen
/
Nomograms
/
Neoplasm Grading
/
Neoplasm Staging
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2014
Type:
Article
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