Resistance to apoptosis should not be taken as a hallmark of cancer / 癌症
Chinese Journal of Cancer
;
(12): 47-50, 2014.
Article
in English
| WPRIM
| ID: wpr-320536
ABSTRACT
In the research community, resistance to apoptosis is often considered a hallmark of cancer. However, pathologists who diagnose cancer via microscope often see the opposite. Indeed, increased apoptosis and mitosis are usually observed simultaneously in cancerous lesions. Studies have shown that increased apoptosis is associated with cancer aggressiveness and poor clinical outcome. Furthermore, overexpression of Bcl-2, an antiapoptotic protein, is linked with better survival of cancer patients. Conversely, Bax, CD95, Caspase-3, and other apoptosis-inducing proteins have been found to promote carcinogenesis. This notion of the role of apoptosis in cancer is not new; cancer cells were found to be short-lived 88 years ago. Given these observations, resistance to apoptosis should not be considered a hallmark of cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Biomarkers, Tumor
/
Lymphoma, B-Cell
/
Treatment Outcome
/
Apoptosis
/
Fas Receptor
/
Proto-Oncogene Proteins c-bcl-2
/
Bcl-2-Associated X Protein
/
Caspase 3
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2014
Type:
Article
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