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Targeted therapy: tailoring cancer treatment / 癌症
Chinese Journal of Cancer ; (12): 363-364, 2013.
Article in English | WPRIM | ID: wpr-320568
ABSTRACT
Targeted therapies include small-molecule inhibitors and monoclonal antibodies, have made treatment more tumor-specific and less toxic, and have opened new possibilities for tailoring cancer treatment. Nevertheless, there remain several challenges to targeted therapies, including molecular identification, drug resistance, and exploring reliable biomarkers. Here, we present several selected signaling pathways and molecular targets involved in human cancers including Aurora kinases, PI3K/mTOR signaling, FOXO-FOXM1 axis, and MDM2/MDM4-p53 interaction. Understanding the molecular mechanisms for tumorigenesis and development of drug resistance will provide new insights into drug discovery and design of therapeutic strategies for targeted therapies.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Nuclear Proteins / Signal Transduction / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Drug Resistance, Neoplasm / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-mdm2 / Forkhead Transcription Factors / TOR Serine-Threonine Kinases Type of study: Prognostic study Limits: Humans Language: English Journal: Chinese Journal of Cancer Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Nuclear Proteins / Signal Transduction / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Drug Resistance, Neoplasm / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-mdm2 / Forkhead Transcription Factors / TOR Serine-Threonine Kinases Type of study: Prognostic study Limits: Humans Language: English Journal: Chinese Journal of Cancer Year: 2013 Type: Article